Identification of bovine trophoblast protein-1, a secretory protein immunologically related to ovine trophoblast protein-1
نویسندگان
چکیده
منابع مشابه
Identification of bovine trophoblast protein-1, a secretory protein immunologically related to ovine trophoblast protein-1.
This paper demonstrates that a group of proteins, representing a major secretory component of cattle conceptuses, is immunologically related to ovine trophoblast protein-1 (oTP-1), a principal product of culture Day 13 to 21 sheep conceptuses. Conceptuses from cows (Day 17-18) and ewes (Day 16-17) were cultured for 24 h in the presence of L-[3H]leucine. By using a rabbit antiserum to oTP-1 and ...
متن کاملInhibition of lymphocyte proliferation by bovine trophoblast protein-1 (type I trophoblast interferon) and bovine interferon-alpha I1.
Bovine trophoblast protein-1 (bTP-1) is a Type I interferon secreted by the bovine trophoblast from about Day 15 of pregnancy. It is not known whether bTP-1 has functional properties in common with other interferons. The aim of the present study was to determine whether bTP-1 inhibits proliferation of lymphocytes induced by mitogens, mixed lymphocyte cultures (MLC) and interleukin-2 (IL-2) and,...
متن کاملOvine Trophoblast Protein-1 Antiproliferative Activity of a Pregnancy Recognition Hormone,
Ovine trophoblast protein-1 (oTP-1 ) is the a-interferon (IFNa) variant, secreted by conceptuses and referred to as type I trophoblast interferon, that is responsible for maternal recognition of pregnancy in sheep. We have previously shown that oTP-1 is as potent an antiviral agent as any known IFN. IFNs also possess anticellular activity and are, in fact, used in cancer therapy and have been f...
متن کاملLocalization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein 1.
Ovine trophoblast protein 1 (oTP-1) is the interferon alpha (IFN-alpha) variant with potent antiviral activity and low toxicity that is responsible for maternal recognition of pregnancy in sheep. To examine the structure/function basis for the potent antiviral activity of oTP-1, we have exploited the direct approach of synthetic peptide competition with oTP-1 for receptor, using N-terminal oTP-...
متن کاملDifferential glycosylation of the components of the bovine trophoblast protein-1 complex.
The bovine trophoblast protein-1 complex, a major secretory product of the day 17 to 18 conceptus, has been implicated in extension of luteal lifespan during early pregnancy. This glycoprotein complex, identifiable by immunoprecipitation procedures utilizing rabbit antiserum to ovine trophoblast protein-1, exists as seven isomers of two size classes (22 and 24 kDa). Culture of embryos with tuni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reproduction
سال: 1987
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0790083